ArticleAnnals of surgical oncology2025
Is the Clipped Node Enough? Successful Retrieval and False Negative Rate of the Clipped Node After Neoadjuvant Chemotherapy.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- ASO Author Reflections: The Role of the Clipped Node after Neoadjuvant Chemotherapy in the Contemporary Setting.Annals of surgical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundVarious techniques exist to decrease the false negative rate (FNR) of axillary surgical staging post neoadjuvant chemotherapy (NAC). While biopsy-proven positive lymph nodes (LNs) are often clipped prior to NAC, the value of clipped node localization is debated.
methodsWe identified cT0-4c biopsy-proven cN+ breast cancer patients with a clipped LN treated with NAC and definitive surgery (September 2016-July 2024). The axillary staging procedure included sentinel lymph node (SLN) surgery or targeted axillary dissection (TAD). Frequency of the clipped node being an SLN and FNR of the clipped node versus all nodes removed during SLN surgery/TAD were determined.
resultsOf 540 patients with 541 cN+ breasts with cancer, 456 patients had a positive LN clipped prior to NAC and underwent axillary surgical staging (404 TAD, 52 SLN surgery). The clipped node was retrieved in 93% of eligible patients (96% TAD vs. 77% SLN surgery; p < 0.001) and, if retrieved, was an SLN in 86% (85% TAD vs. 92.5% SLN surgery; p = 0.20). The median number of nodes retrieved was four for both SLN surgery and TAD. Among 204 patients with ypN+ disease who had the clipped node and additional non-clipped nodes removed, FNR of the clipped node was 5.4%, and FNR of the SLNs was 4.9%.
conclusionIn a contemporary NAC cohort of cN+ patients, the clipped node was retrieved and was a SLN in most cases. When compared with all nodes removed during SLN surgery/TAD, the clipped node FNR was low, thus supporting the potential for limitation of axillary staging surgery to selective removal of the clipped node alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.