ArticleInternational ophthalmology2025
Unveiling the limitations of OCT-based classification in diabetic epiretinal membranes: a call for integrative vascular and structural assessment with OCT-A.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Diagnostic Performance of ChatGPT-4o in Classifying Idiopathic Epiretinal Membrane Based on Optical Coherence Tomography.Journal of clinical medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGovetto's optical coherence tomography (OCT)-based staging system is widely used for idiopathic epiretinal membranes (ERMs), but its applicability to diabetic ERMs remains unclear. Given the distinct microvascular pathology in diabetes, this study evaluated the system's applicability in diabetic ERMs and compared structural and vascular features of diabetic and idiopathic ERMs using OCT and OCT-angiography (OCT-A).
methodsThis retrospective study included 142 eyes with diabetic ERM, idiopathic ERM, and healthy controls. All subjects underwent comprehensive ophthalmic examination, OCT, and OCT-A imaging. ERMs were staged using Govetto et al.'s classification. Correlations between visual acuity (VA), ERM stage, OCT metrics, and OCT-A parameters were analyzed. The macular vessel density ratio (MVR) was also calculated.
resultsEctopic inner foveal layer (EIFL), microcystoid changes, and retinal layer thicknesses were comparable across stages, with EIFL increasing as stages advanced in both groups. EIFL and outer foveal thickness showed no significant group differences, but EIFL was consistently thinner in diabetic cases. Diabetic ERMs had lower vessel densities (VD) and significantly reduced choriocapillaris flow area. Only in the diabetic group were strong correlations observed between outer retinal layer values and VD, as well as between VA, choriocapillaris flow, retinal thickness, and deep macular VD.
conclusionAlthough Govetto's OCT-based classification aligns with structural progression in both ERM types, it does not reflect the vascular alterations seen in diabetic ERMs. These findings suggest that structural staging alone may be insufficient in diabetic cases. Awareness of vascular differences and integration of OCT-A parameters may improve interpretation and guide prognosis in diabetic ERMs.
Indexed as
Identifiers
40802083What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.