SynthesisEuropean journal of nutrition2025
Protein intake and cardiovascular diseases: an umbrella review of systematic reviews for the evidence-based guideline on protein intake of the German Nutrition Society.
Synthesis in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- [Protein intake and preservation of function in old age : Current evidence and present research gaps].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Dietary Macronutrient Intake and Vascular Health in Patients with Long COVID: The BioICOPER Study.Nutrients · 2026Article
- Selected Nutraceuticals in Metabolic Syndrome: Molecular Mechanisms and Clinical Implications.Biomedicines · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD).
methodsPubMed, Embase and Cochrane Database were systematically searched for systematic reviews (SRs) of prospective studies with or without meta-analysis (MA) published between January 2012 and April 2024. Methodological quality, outcome-specific certainty of evidence, and overall certainty of evidence were assessed using established tools and predefined criteria.
resultsTen SRs were considered eligible for the umbrella review; all were based on prospective cohort studies, and six conducted a MA. Dietary intakes of total, animal and plant protein were not associated with the risk of CHD or stroke. For CHD, the overall certainty of evidence for the absence of an association was "probable" for total, animal and plant protein. For stroke and total CVD, the overall certainty of evidence was rated as "possible" for the absence of an association with the intake of total protein and plant protein and insufficient for animal protein intake.
conclusionGiven that most SRs on dietary protein intake did not indicate an association, it seems that protein intake plays no major role in the development of CVD. This investigation was registered at PROSPERO as CRD42018082395.
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Registered trials
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