Observational studyPediatric radiology2025
Unsedated cerebrovascular reactivity imaging is well-tolerated in children.
Observational study in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundUnsedated MRI use in pediatric clinical and research settings is often feasible, but advanced imaging techniques like cerebrovascular reactivity (CVR) may affect tolerability of unsedated MRIs. Exogenous carbon dioxide (CO
objectiveWe hypothesized that children would tolerate MRI with exogenous CO MATERIALS AND
methodsChildren with and without sickle cell disease and/or reactive airway disease participated in prospective, single-site unsedated MRI observational studies and completed a post-scan questionnaire. A RespirAct® device delivered CO
resultsOne-hundred children participated, with a median age of 14.0 years [11.0, 16.3]. Sickle cell disease and/or reactive airway disease was present in 35% (35/100) and 16% (16/100), respectively. CVR sessions occurred in 75 participants, while 25 had MRI only. All children tolerated and completed the scans; 77% (58/75) had usable CVR data. Motion was similar between those with and without CVR (P=0.33). Children undergoing CVR were more likely to report symptoms, mainly shortness of breath (42/75 vs 3/25; P<0.001), compared to MRI only. Eleven children reported mild, temporary symptoms post-CVR scan; all resolved within a few hours. No serious adverse events occurred. Three children (CVR group) reported unwillingness to repeat the scan.
conclusionChildren tolerate MRI with exogenous CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.