Evidence map›Paper›PMID 40802028›Full record

ArticleAging clinical and experimental research2025

Are low-trauma fractures all fragility fractures? Insights into musculoskeletal and body composition characteristics of community-dwelling post-menopausal women with a recent fracture.

Varvara Chatzipetrou, Thierry Chevalley, Ivan Padlina, Marina Portela, Serge Ferrari, Emmanuel Biver

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Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Varvara ChatzipetrouDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Thierry ChevalleyDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Ivan PadlinaDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Marina PortelaDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Serge FerrariDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland.
Emmanuel BiverDivision of Bone Diseases, Department of Medicine, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205, Geneva, Switzerland. Emmanuel.Biver@hug.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe incidence of fragility fractures is increasing among community-dwelling postmenopausal women. Sarcopenia and obesity are significant risk factors for fractures, independent of osteoporosis. This study aims to investigate the prevalence of sarcopenia and obesity, as well as bone microstructure, according to osteoporotic status and fracture sites in older women with recent low-trauma fractures.

methodsThis cross-sectional study included 135 community-dwelling postmenopausal women aged 65 and older, evaluated within six months of experiencing a low-trauma fracture (resulting from a fall from standing height or less) occurring at the humerus, proximal femur, vertebrae, pelvis, forearm, or ankle. Participants were recruited either prospectively through the Fracture Liaison Service (FLS) at the Bone Disease Department of Geneva University Hospitals (HUG) (n = 90) or retrospectively from the Geneva Retirees Cohort (GERICO) (n = 45). Bone mineral density (BMD) and body composition were assessed using dual-energy X-ray absorptiometry (DXA), muscle strength was measured by handgrip strength (HGS), and bone microstructure was evaluated using high-resolution peripheral quantitative computed tomography (HR-pQCT). RESULTS AND DISCUSSION: The prevalence of sarcopenia varied, with the overall prevalence across all definitions being 25%. It was significantly higher in osteoporotic women than in women with normal BMD (39% versus 6%, respectively, p = 0.014) and osteopenia (39% versus 20% respectively, p < 0.05). The prevalence of obesity was 24%, with particularly high rates observed among women with normal BMD (61%) and those with ankle or humerus fractures (43%, and 38%, respectively). Notably, 33% of women with major osteoporotic fractures (MOF) presented with normal BMD and without sarcopenia or obesity.

conclusionsA significant proportion of women with apparent low-trauma MOF does not have osteoporosis nor alterations of body composition (sarcopenia or obesity). The determinants of fracture risk in these women remain unclear and further investigations are required to better address secondary fracture prevention in this context.

Indexed as

Body CompositionFractures, BoneOsteoporotic FracturesPostmenopauseSarcopeniaAbsorptiometry, PhotonAgedAged, 80 and overBone DensityCross-Sectional StudiesFemaleHand StrengthHumansIndependent LivingObesityPrevalenceBone microstructureFragility fractureObesityOsteoporosisSarcopenia

Identifiers

PMID40802028
PMCPMC12350515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.