Evidence map›Paper›PMID 40802026›Full record

ArticleAging clinical and experimental research2025

Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study.

Ya-Nan Zheng, Peng Qiu, Hui-Huan Luo, Ren-Jie Chen, Xue-Qiang Wang, Pei-Jie Chen

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In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ya-Nan Zheng *Department of Sport Rehabilitation, Shanghai University of Sport, 399 Changhai Road, Yangpu District, Shanghai, 200438, China.
Peng Qiu *Department of Rehabilitation, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hui-Huan LuoSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Ren-Jie ChenSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, 200032, China.
Xue-Qiang WangRehabilitation Medicine Center, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China. wangxueqiang@wmu.edu.cn.
Pei-Jie ChenDepartment of Sport Rehabilitation, Shanghai University of Sport, 399 Changhai Road, Yangpu District, Shanghai, 200438, China. chenpeijie@sus.edu.cn.

Funding

National Natural Science Foundation of China 82372578Science and Technology Commission of Shanghai Municipality 21S31902400
6 · The paper itself

Abstract

introductionThe causal association between pulmonary function and Alzheimer's disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.

methodsWe conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV

resultsOver a median follow-up of 12.8 years (10.3-15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32-2.48; FEV

conclusionOur findings suggest the potential causal association between high FEV

Indexed as

Alzheimer DiseaseLungAgedFemaleForced Expiratory VolumeGenome-Wide Association StudyHumansIncidenceMaleMendelian Randomization AnalysisMiddle AgedProportional Hazards ModelsProspective StudiesRespiratory Function TestsRisk FactorsVital CapacityAlzheimer’s diseaseCohort studyMendelian randomizationPulmonary functionRisk factors

Identifiers

PMID40802026
PMCPMC12350532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.