Evidence map›Paper›PMID 40802003›Full record

ArticleAging clinical and experimental research2025

Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals.

Jingyi Xu, Ruyi Qu, Keke Yang, Yuezhu Wang, Meiyun Nie, Xiaodong Qi, Huajun Zheng, Ling Yang

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In one paragraph

Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jingyi Xu *Department of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China.
Ruyi Qu *Department of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China.
Keke Yang *Department of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China.
Yuezhu Wang *Shanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China.
Meiyun NieDepartment of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China.
Xiaodong QiDepartment of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China.
Huajun ZhengShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, 200237, China. zhenghj@chgc.sh.cn.
Ling YangDepartment of Geriatrics, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, 200434, China. 2205603@tongji.edu.cn.

Funding

Science and Technology Commission of Shanghai Municipality NO.24692113500Shanghai Fourth People's Hospital Affiliated to Tongji University NO. sykyqd06401Shanghai Municipal Health Commission of Hongkou, Clinical Key Support Specialty - Geriatric Medicine NO. HKLCFC202412Shanghai Municipal Health Commission of Hongkou, Major Medical Research Project NO. Hong Wei 2301-03
6 · The paper itself

Abstract

BACKGROUND AND

aimsPulmonary infections are a major health concern for the elderly, because of their high morbidity and mortality rates. With the growing world's aging population, it is crucial to prioritize the health of elderly individuals. This study aimed to explore the associations between oral and gut microbiota and pulmonary infections.

methodsThroat swabs and stool samples were collected from elderly patients aged 78-98 years and divided into four groups: Control, Infection, Re-Infection, and Re-None. The microbiota were analyzed via 16S rRNA gene sequencing, and the functional predictions were imputed using PICRUSt with MetaCyc pathway annotation.

resultsSignificant differences were observed in oral and gut microbiota diversity between the control and test groups. Patients with pneumonia showed a significant increase in Staphylococcus aureus abundance in the oral microbiota compared to the Control group, while those with recurrent pneumonia showed elevated, Klebsiella pneumoniae levels. In the gut microbiota, Enterococcus hirae alone that was significantly enriched in all three test groups. Furthermore, PICRUSt2 analysis indicated an increased relative abundance of genes associated with the degradation of D-glucarate and D-galactarate pathways in patients with recurrent infections.

conclusionOral and gut microbiota diversity showed significant differences between patients with recurrent pneumonia and common pneumonia pneumonia-infected patients. The higher prevalence of both S. aureus and K. pneumoniae in the oral microbiota offers crucial insights into the pneumonia etiology. Specifically, the increased abundance of K. pneumoniae may contribute significantly to the heightened lung infections susceptibility among elderly individuals.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaMouthPneumoniaAgedAged, 80 and overBacteriaFemaleHumansKlebsiella pneumoniaeMaleRNA, Ribosomal, 16SStaphylococcus aureusRNA, Ribosomal, 16S16S rRNA geneElderly individualsGut microbiotaOral microbiotaRecurrent pulmonary infections

Identifiers

PMID40802003
PMCPMC12350567

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