ArticleBrain structure & function2025
A comprehensive and reliable protocol for manual segmentation of the human claustrum using high-resolution MRI.
Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Anatomic Interactive Atlas of the Loggerhead Sea Turtle (Animals : an open access journal from MDPI · 2026Article
- A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation.Human brain mapping · 2025Article
- High-resolution dataset of manual claustrum segmentation.Data in brief · 2024Article
- AM-UNet: automated mini 3D end-to-end U-net based network for brain claustrum segmentation.Multimedia tools and applications · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
The claustrum is a thin gray matter structure in each brain hemisphere, characterized by exceptionally high connectivity with nearly all brain regions. Despite extensive animal studies on its anatomy and function and growing evidence of claustral deficits in neuropsychiatric disorders, its specific roles in normal and abnormal human brain function remain largely unknown. This is primarily due to its thin and complex morphology, which limits accurate anatomical delineation and neural activity isolation in conventional in vivo neuroimaging. To facilitate future neuroimaging studies, we developed a comprehensive and reliable manual segmentation protocol based on a cellular-resolution brain atlas and high-resolution (0.7 mm isotropic) MRI data. The protocols involve detailed guidelines to delineate the entire claustrum, including the inferior parts that have not been clearly described in earlier MRI studies. Additionally, we propose a geometric method to parcellate the claustrum into three subregions (the dorsal, ventral, and temporal claustrum) along the superior-to-inferior axis. The mean bilateral claustrum volume in 10 young adults was 3307.5 mm
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