Evidence map›Paper›PMID 40801950›Full record

ReviewCellular and molecular life sciences : CMLS2025

Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion.

Klaus Ebnet, Michel Aurrand-Lions

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Klaus EbnetInstitute-associated Research Group "Cell adhesion and cell polarity", Institute of Medical Biochemistry, ZMBE, University of Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany. ebnetk@uni-muenster.de.ORCID http://orcid.org/0000-0002-0417-7888
Michel Aurrand-LionsAix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM Equipe Labellisée, Ligue, Marseille, 2020, France. michel.aurrand-lions@inserm.fr.ORCID http://orcid.org/0000-0002-8361-3034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive system, or cells of the hematopoietic system. Through trans-homophilic as well as trans-heterophilic interactions with the JAM family member JAM-B and with members of the integrin family JAM-C regulates diverse processes including epithelial barrier formation, leukocyte- endothelial interactions and transendothelial migration, neuronal cell migration along glial fibers, myelin sheath integrity, and germ cell migration. In this article, we review the biological activities of JAM-C, including its basic organization, its extracellular and intracellular interaction partners, and its diverse physiological functions.

Indexed as

Cell AdhesionCell Adhesion MoleculesAnimalsCell MovementHumansCell Adhesion MoleculesCell adhesionCell-Cell contactsCell PolarityJAM-CJunctional adhesion moleculesMigrationTight junctions

Identifiers

PMID40801950
PMCPMC12350915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.