ArticleCerebral cortex (New York, N.Y. : 1991)2025
The emergence of genetic variants linked to brain and cognitive traits in human evolution.
Article in Cerebral cortex (New York, N.Y. : 1991), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
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6 authors.
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Abstract
Human evolution involved major anatomical transformations, including a rapid increase in brain volume over the last 2 million years. Examination of fossil records provides insight into these physical changes but offers limited information on the evolution of brain function and cognition. A complementary approach integrates genome dating from the Human Genome Dating Project with genome-wide association studies to trace the emergence of genetic variants linked to human traits over 5 million years. We find that genetic variants underlying cortical morphology (~300,000 years, P = 4 × 10-28), fluid intelligence (~500,000 years, P = 1.4 × 10-4), and psychiatric disorders (~475,000 years, P = 5.9 × 10-33) emerged relatively recently in hominin evolution. Among psychiatric phenotypes, variants associated with depression (~24,000 years, P = 1.6 × 10-4) and alcoholism-related traits (~40,000 years, P = 5.2 × 10-12) are the youngest. Genes with recent evolutionary modifications are involved in intelligence (P = 1.7 × 10-6) and cortical area (P = 3.5 × 10-4) and exhibit elevated expression in language-related areas (P = 7.1 × 10-4), a hallmark of human cognition. Our findings suggest that recently evolved genetic variants shaped the human brain, cognition, and psychiatric traits.
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