Evidence map›Paper›PMID 40801885›Full record

SynthesisInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2026

Intra-arterial thrombolysis after successful endovascular reperfusion for large vessel occlusion stroke: A meta-analysis of randomized seven controlled trials.

Ali Mortezaei, Nadir Al-Saidi, Yan Lin Li, Vivek S Yedavalli, Robert W Regenhardt, Adam A Dmytriw

Expression of concernAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Intra-arterial tenecteplase in acute ischemic stroke after successful endovascular thrombectomy: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ali MortezaeiStudent Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.ORCID 0000-0002-7217-3264
Nadir Al-SaidiCentral Michigan University, College of Medicine, Mount Pleasant, MI, USA.ORCID 0009-0004-2004-2694
Yan Lin LiDepartment of Neuroradiology, JohnRadcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-1722-4188
Vivek S YedavalliDepartment of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD, USA.
Robert W RegenhardtDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2958-3484
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0131-5699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundAlthough thrombectomy is the standard of care for acute ischemic stroke (AIS) due to large-vessel occlusion (LVO), many patients fail to achieve disability-free recovery, highlighting the need for adjunctive therapy to improve outcomes.PurposeThis systematic review and meta-analysis aimed to compare intra-arterial thrombolysis (IAT) and placebo following the successful recanalization of AIS-LVO.Materials and MethodsA systematic literature review of four databases was performed. Categorical and continuous outcomes were calculated using Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs), respectively. Any potential heterogeneity was resolved through leave-one-out influence analysis. Risk of bias was assessed using the RoB2 tool. Our study was not registered in PROSPERO. The primary analysis included three published RCTs; four additional trials, including posterior circulation or preliminary data, were incorporated in sensitivity analyses to validate robustness.ResultsA total of three trials with enrolled patients 1187 were included in the study. Four additional trials were also included only for sensitivity analysis. The findings showed that patients who received IAT had a significantly higher rate of 90-day functional excellence (RR = 1.15, 95%CI = 1.01-1.3,

Indexed as

Endovascular ProceduresFibrinolytic AgentsIschemic StrokeStrokeThrombolytic TherapyHumansRandomized Controlled Trials as TopicReperfusionTreatment OutcomeFibrinolytic Agentsacute ischemic strokeendovascular thrombectomyIntra-arterial thrombolysislarge vessel occlusionsuccessful reperfusion

Identifiers

PMID40801885
PMCPMC12350307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.