SynthesisDeutsches Arzteblatt international2025
Mortality After Osteoporotic Vertebral Body Fractures: Cement Augmentation Versus Conservative Treatment—A Systematic Review and Meta-Analysis.
Synthesis in Deutsches Arzteblatt international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Health-related Quality of Life After Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures.Current osteoporosis reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporotic vertebral body fractures are associated with a 1-year mortality of 28%, a figure similar to that for hip fractures. Retrospective registry studies from multiple countries have shown a survival advantage in patients treated with an augmentation procedure.
methodsWe carried out a systematic review of publications retrieved from the PubMed, Livivo, Cochrane Central, and Web of Science databases, and from the internet at large via Google Scholar. Studies were selected for analysis if they included a comparison of mortality in patients with osteoporotic vertebral body fractures who were treated conservatively versus those who were treated with cement augmentation. We also carried out a pooled quantitative analysis based on the findings of all studies in which a hazard ratio (HR) comparing the two modes of treatment was reported.
results22 publications met the inclusion criteria, including two randomized, controlled trials (RCTs). The two RCTs and 8 of the remaining studies showed no significant difference in mortality between the two groups; a significant positive effect of augmentation was reported in a further 11 studies, and a significant negative effect in 1. 11 studies were suitable for inclusion in the quantitative analysis. The pooled HR for death was 0.91 (95% confidence interval [0.73; 1.15]; p = 0.39), i.e., mildly in favor of augmentation, but statistically insignificant.
conclusionA wide variety of confounders may have led to an overestimation, in retrospective studies, of the survival advantage putatively conferred by cement augmentation of vertebral body fractures compared to conservative treatment. Our systematic review and meta-analysis revealed no significant association of either form of treatment with a higher survival rate.
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Registered trials
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