ArticleJournal of clinical laboratory analysis2025
Assessment of Mortality Risk in Patients With Community-Acquired Pneumonia: Role of Novel Inflammatory Biomarkers.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Association between blood urea nitrogen-to-creatinine ratio trajectories and mortality in patients with severe pneumonia requiring invasive mechanical ventilation: a Medical Information Mart for Intensive Care IV (MIMIC-IV) database analysis.Journal of thoracic disease · 2026Article
- The Impact of the Hemoglobin-to-Lactate Ratio (HLR) on Clinical Outcomes and Prognosis in Pneumonia Patients Presenting to the Emergency Department.Diagnostics (Basel, Switzerland) · 2026Article
- Systemic inflammatory indices and 28-day mortality in severe pneumonia: a retrospective single-center exploratory study.Frontiers in medicine · 2026Article
- Systemic Inflammatory Indices (SII and SIRI) in 30-Day Mortality Risk Stratification for Community-Acquired Pneumonia: A Study Alongside CURB-65 and PSI.Pathogens (Basel, Switzerland) · 2025Article
- Prognostic significance of the CALLY index for cancer risk and survival: evidence from NHANES 2001-2018.World journal of surgical oncology · 2025Article
- Comparison of the systemic inflammatory response index and the systemic immune-inflammatory index in pediatric community-acquired pneumonia caused by respiratory syncytial virus andFrontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPneumonia is a lung parenchyma infection with clinical presentations ranging from mild to life-threatening. Its severity depends on factors such as the causative pathogen, the host's immune response, and existing comorbidities. This study aimed to investigate the prognostic value of novel inflammatory biomarkers for predicting in-hospital mortality in patients with community-acquired pneumonia (CAP).
methodsThis retrospective cross-sectional study included 207 hospitalized patients diagnosed with clinically and radiologically confirmed pneumonia. Laboratory data collected upon admission included complete blood count parameters, C-reactive protein (CRP), creatinine, and albumin levels. Systemic inflammatory biomarkers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), CRP-to-albumin ratio (CAR), CRP-to-lymphocyte ratio (CLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), prognostic nutritional index (PNI), and C-reactive protein-albumin-lymphocyte (CALLY) index were calculated.
resultsThe cohort was predominantly male (69%, n = 142) with a mean age of 62.1 ± 16.3 years. The median hospital stay was 8 days, with an 11% mortality rate. Malignancy was more frequent in the nonsurvivor group (p = 0.001). Nonsurvivors had significantly lower hemoglobin (p < 0.001) and albumin (p = 0.004) levels, while CRP (p = 0.024) and creatinine (p = 0.002) were elevated. NLR (p = 0.009), CAR (p = 0.011), CLR (p = 0.006), SII (p = 0.013), and SIRI (p = 0.024) were higher in nonsurvivors, while PNI (p = 0.010) and CALLY (p = 0.003) were lower.
conclusionNovel inflammatory biomarkers, particularly the CALLY index, are valuable for mortality prediction in CAP, aiding in risk stratification and early management.
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