Evidence map›Paper›PMID 40801739›Full record

ReviewNanomaterials (Basel, Switzerland)2025

Immunomodulatory Effects of Gold Nanoparticles: Impacts on Immune Cells and Mechanisms of Action.

Khadijeh Koushki, Prapannajeet Biswal, Geraldine Vidhya Vijay, Mahvash Sadeghi, Sajad Dehnavi, Ngoc Tuyet Tra, Sai Kumar Samala, Mahdieh Yousefi Taba, Arjun Balaji Vasan, Emily Han and 2 more

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Khadijeh KoushkiVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.
Prapannajeet BiswalVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0009-0005-6659-3157
Geraldine Vidhya VijayVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.
Mahvash SadeghiFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran.
Sajad DehnaviAllergy Research Center, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran.
Ngoc Tuyet TraVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.
Sai Kumar SamalaVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.
Mahdieh Yousefi TabaFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad 13944-91388, Iran.
Arjun Balaji VasanVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0009-0004-3656-7639
Emily HanDepartment of Biosciences, Rice University, Houston, TX 77251-1892, USA.
Yuri MackeyevVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0000-0003-4456-0563
Sunil KrishnanVivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, Houston, TX 77030, USA.ORCID 0000-0002-1340-4771

Funding

Rational translation of gold nanoparticle mediated radiosensitization tothe clinicR01CA257241 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Sang Hyun Cho, Sunil Krishnan · 2021 to 2026
$3.1M
In situ cancer cell specific biomineralization to overcome nanoparticle delivery barriers and sensitize pancreatic cancer to radiotherapyR01CA274415 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Sang Hyun Cho, Sunil Krishnan · 2022 to 2026
$3.0M
NCI NIH HHS R01 CA257241NCI NIH HHS R01 CA274415NIH HHS 5R01CA257241-05NIH HHS 5R01CA274415-03
6 · The paper itself

Abstract

Traditional anti-inflammatory medications-such as corticosteroids, biological agents, and non-steroidal anti-inflammatory drugs-are commonly employed to mitigate inflammation, despite their potential for debilitating side effects. There is a growing need for alternative next-generation therapies for symptomatic, unchecked, and/or detrimental inflammation with more favorable adverse effect profiles. The long history of use of gold salts as anti-inflammatory agents and the more recent exploration of gold nanoparticle (AuNP) formulations for clinical indications suggest that the targeted delivery of nanoparticles to inflammatory sites may be a promising approach worth investigating. Coupled with peptides that specifically target immune cells, AuNPs could potently counteract inflammation. Here, we provide an overview of the selective infiltration of AuNPs into immune cells and summarize their interactions with and impact on these cells. Additionally, we provide a comprehensive mechanistic summary of how AuNPs exert their anti-inflammatory effects.

Indexed as

adaptive immunityanti-inflammatorygold nanoparticleinflammationinnate immunity

Identifiers

PMID40801739
PMCPMC12348064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.