Evidence map›Paper›PMID 40801636›Full record

ArticleCells2025

Purified Cornel Iridoid Glycosides Attenuated Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury via Morroniside and Loganin Targeting Nrf2/NQO-1/HO-1 Signaling Pathway.

Zhaoyang Wang, Fangli Xue, Enjie Hu, Yourui Wang, Huiliang Li, Boling Qiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Protective effects ofRedox report : communications in free radical research · 2026
    Article
  2. Article
  3. Journal of pharmacopuncture · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhaoyang WangKey Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an 710069, China.ORCID 0000-0001-8253-4417
Fangli XueKey Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an 710069, China.
Enjie HuKey Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an 710069, China.
Yourui WangKey Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an 710069, China.
Huiliang LiWolfson Institute for Biomedical Research, Division of Medicine, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK.
Boling QiaoKey Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, No. 229 Taibai North Road, Xi'an 710069, China.ORCID 0000-0002-4365-2485

Funding

National Natural Science Foundation of China 81973452 and 82111530156
6 · The paper itself

Abstract

Oxidative stress significantly contributes to the exacerbation of brain damage during cerebral ischemia-reperfusion injury (CIR/I). In our previous study, purified cornel iridoid glycoside (PCIG), consisting of morroniside (MOR) and loganin (LOG), showed neuroprotective effects against CIR/I. To further explore the antioxidative effects and underlying molecular mechanisms, we applied PCIG, MOR, and LOG to rats injured by middle cerebral artery occlusion/reperfusion (MCAO/R) as well as H

Indexed as

Brain IschemiaCornusGlycosidesIridoid GlycosidesIridoidsNF-E2-Related Factor 2Oxidative StressReperfusion InjurySignal TransductionAnimalsHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hydrogen PeroxideInfarction, Middle Cerebral ArteryKelch-Like ECH-Associated Protein 1MaleGlycosidesHeme Oxygenase-1Heme Oxygenase (Decyclizing)Hmox1 protein, ratHydrogen PeroxideIridoid GlycosidesIridoidsKEAP1 protein, ratKelch-Like ECH-Associated Protein 1loganinmorronisideNAD(P)H Dehydrogenase (Quinone)Nfe2l2 protein, ratNF-E2-Related Factor 2NQO1 protein, ratReactive Oxygen Speciescerebral ischemia-reperfusion injuryloganinmorronisideNrf2 signaling pathwayoxidative stresspurified cornel iridoid glycosides

Identifiers

PMID40801636
PMCPMC12345668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.