Evidence map›Paper›PMID 40801581›Full record

ArticleCells2025

Intranasal Mitochondrial Transplantation Restores Mitochondrial Function and Modulates Glial-Neuronal Interactions in a Genetic Parkinson's Disease Model of

Jui-Chih Chang, Chin-Hsien Lin, Cheng-Yi Yeh, Mei-Fang Cheng, Yi-Chieh Chen, Chi-Han Wu, Hui-Ju Chang, Chin-San Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jui-Chih ChangCenter of Regenerative Medicine and Tissue Repair, Institute of ATP, Changhua Christian Hospital, Changhua 50094, Taiwan.ORCID 0000-0002-8349-862X
Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, Taipei 10051, Taiwan.
Cheng-Yi YehCenter of Regenerative Medicine and Tissue Repair, Institute of ATP, Changhua Christian Hospital, Changhua 50094, Taiwan.
Mei-Fang ChengDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan.ORCID 0000-0002-9359-0606
Yi-Chieh ChenDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan.ORCID 0009-0008-6753-8952
Chi-Han WuDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan.
Hui-Ju ChangCenter of Regenerative Medicine and Tissue Repair, Institute of ATP, Changhua Christian Hospital, Changhua 50094, Taiwan.
Chin-San LiuVascular and Genomic Center, Institute of ATP, Changhua Christian Hospital, Changhua 50094, Taiwan.ORCID 0000-0001-8241-9654

Funding

Changhua Christian Hospital, Taiwan 113-CCH-IRP-028Ministry of Science and Technology, Taiwan MOST 108-2321-B-002-060-MY2 and NSTC 113-2314-B-371-014
6 · The paper itself

Abstract

The intranasal delivery of exogenous mitochondria is a potential therapy for Parkinson's disease (PD). The regulatory mechanisms and effectiveness in genetic models remains uncertain, as well as the impact of modulating the mitochondrial permeability transition pore (mPTP) in grafts. Utilizing

Indexed as

Electron Transport Complex IIIMitochondriaMutationNeurogliaNeuronsParkinson DiseaseAdministration, IntranasalAnimalsCyclosporineDisease Models, AnimalMaleMiceMice, Inbred C57BLCyclosporineElectron Transport Complex IIIcyclosporine Aglial modulationinflammatory cytokinesintranasal deliverymitochondrial functionmitochondrial transplantationneuroprotectionParkinson’s diseasestriatal astrocytesstriatal oligodendrocytesUQCRC1 mutation (p.Tyr314Ser) knock-in mice

Identifiers

PMID40801581
PMCPMC12346496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.