Evidence map›Paper›PMID 40801536›Full record

ArticleApplied and environmental microbiology2025

Commensal acidification of specific gut regions produces a protective priority effect against enteropathogenic bacterial infection.

Jane L Yang, Haolong Zhu, Puru Sadh, Kevin Aumiller, Zehra T Guvener, William B Ludington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Microbiotherapy: an emerging adjunct for burn wound healing.Frontiers in cellular and infection microbiology · 2026
    Review
  2. Is it time to assignApplied and environmental microbiology · 2025
    Article
  3. Review
  4. Review
  5. Infection and immunity · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jane L Yang *Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA.
Haolong Zhu *Division of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, Maryland, USA.ORCID 0000-0002-9056-0268
Puru SadhDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Kevin AumillerDivision of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, Maryland, USA.
Zehra T GuvenerDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, USA.
William B LudingtonDivision of Biosphere Sciences and Engineering, Carnegie Institution for Science, Baltimore, Maryland, USA.ORCID 0000-0001-9637-4493

Funding

Developing a reduced complexity model gut microbiome in the behavior model, Drosophila melanogasterDP5OD017851 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI LUDINGTON, WILLIAM BASIL · 2013 to 2017
$2.0M
Host mechanisms of gut colonization by commensal bacteria that affect lifespanR01DK128454 · NIDDK · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2022 to 2024
$1.2M
Serine-rich repeat proteins in evolution of Lactobacillus-host specificityR21AI173779 · NIAID · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI LUDINGTON, WILLIAM BASIL · 2023 to 2024
$452k
National Science Foundation IOS 2032985National Science Foundation IOS 2144342NIAID NIH HHS R21 AI173779NIDDK NIH HHS R01 DK128454NIH HHS DP5 OD017851NIH HHS DP5OD017851NIH HHS R01DK128454NIH HHS R21AI173779
6 · The paper itself

Abstract

The commensal microbiome has been shown to protect against newly introduced enteric pathogens in multiple host species, a phenomenon known as a priority effect. Multiple mechanisms can contribute to this protective priority effect, including antimicrobial compounds, nutrient competition, and pH changes. In

Indexed as

IntestinesSerratiaAcidsAnimalsColony Count, MicrobialDrosophila melanogasterFemaleLactobacillaceaeSymbiosisAcidsacidificationDrosophilagut microbiomeLactobacilluspriority effectSerratia

Identifiers

PMID40801536
PMCPMC12442404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.