Evidence map›Paper›PMID 40801406›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Topological Scaffold-Based Trispecific Recombinant Protein-Drug Conjugates for Solid Tumor Eradication.

Huiyi Jiang, Yang Yuan, Xiaoke Zhang, Weizhi Chen, Hui Mao, Baorui Liu, Xiqun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiyi JiangMOE Key Laboratory of High Performance Polymer Materials & Technology and State Key Laboratory of Analytical Chemistry for Life Science, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Yang YuanMOE Key Laboratory of High Performance Polymer Materials & Technology and State Key Laboratory of Analytical Chemistry for Life Science, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Xiaoke ZhangMOE Key Laboratory of High Performance Polymer Materials & Technology and State Key Laboratory of Analytical Chemistry for Life Science, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Weizhi ChenMOE Key Laboratory of High Performance Polymer Materials & Technology and State Key Laboratory of Analytical Chemistry for Life Science, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.
Hui MaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, 30322, USA.
Baorui LiuThe Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210000, China.
Xiqun JiangMOE Key Laboratory of High Performance Polymer Materials & Technology and State Key Laboratory of Analytical Chemistry for Life Science, and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P. R. China.ORCID https://orcid.org/0000-0003-0483-0282

Funding

Basic Research Program of Jiangsu Province BK20244003National Key Research and Development Program of China 2024YFB3814603National Natural Science Foundation of China 52333003National Natural Science Foundation of China 52373288National Natural Science Foundation of China 92163214Natural Science Foundation of Jiangsu Province BK20202002
6 · The paper itself

Abstract

Topology structure of proteins plays vital roles on their bioactivity and property. However, the understanding of how the biological effect of active targeting groups varies with different spatial positions in the recombinant protein scaffold is poor. Here a three trispecific recombinant heterotrimeric proteins and their drug conjugates are reported with a star and linear topology structure prepared by genetically encoded fusion and SpyTag-SpyCatcher technology, which can simultaneously bind the human epidermal growth factor receptor 1 and 2 as well as integrin α

Indexed as

Antineoplastic AgentsCamptothecinNeoplasmsRecombinant ProteinsAnimalsErbB ReceptorsHeLa CellsHumansMiceRecombinant Fusion ProteinsAntineoplastic AgentsCamptothecinErbB ReceptorsRecombinant Fusion ProteinsRecombinant Proteinsantitumor therapydrug deliverynanobodyrecombinant proteintrispecificity

Identifiers

PMID40801406
PMCPMC12499393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.