Evidence map›Paper›PMID 40801323›Full record

ArticleImmunity, inflammation and disease2025

Human Umbilical Cord Mesenchymal Stem Cells Modulate Cytokine Secretion of CD4

Lu Jin, Meng Ding, Shaoxin Cui, Lin Yang, Jingjing He, Xiaoping Wang, Fei Chang, Jingjing Yu, Yiming Yang, Hongtao Jin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lu JinDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0009-0004-3282-233X
Meng DingDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shaoxin CuiDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Lin YangDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jingjing HeHebei International Joint Research Center on Rheumatic Diseases, Shijiazhuang, Hebei, China.
Xiaoping WangDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Fei ChangDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jingjing YuDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yiming YangDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Hongtao JinDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Min ShiHebei International Joint Research Center on Rheumatic Diseases, Shijiazhuang, Hebei, China.
Jun MaHebei Medical University-University of Galway Stem Cell Research Center, Hebei Medical University, Shijiazhuang, Hebei, China.
Aijing LiuDepartment of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.ORCID https://orcid.org/0000-0002-5762-5592

Funding

This study was funded by Medical Science Research Project of Hebei (20220098, 20240127); Natural Science Foundation of Hebei Province (H2019206387 and H2023206264); Clinical Medicine Excellent Talent Project of Hebei Government Foundation (303-2021-58-18, and ZF2025100); S&T Program of Hebei (19277721D); and Cultivation Program of the Second Hospital of Hebei Medical University (2HN202514).
6 · The paper itself

Abstract

objectiveTreatment with human umbilical cord mesenchymal stem cells (hUC-MSCs) attenuated the clinical manifestations of systemic lupus erythematosus (SLE). We investigated the metabolic mechanism whereby hUC-MSCs modify CD4

methodsThe study enrolled 30 untreated lupus patients and 20 sex, age, and body mass index matched healthy controls (HCs). CD4

resultsCompared with HCs, the enhanced glycolysis and mitochondrial oxygen consumption of SLE-CD4

conclusionsThe hUC-MSCs treatment inhibited overactive glucose metabolism of SLE-CD4

Indexed as

CD4-Positive T-LymphocytesCytokinesHSP90 Heat-Shock ProteinsLupus Erythematosus, SystemicMesenchymal Stem CellsAdultFemaleGlucoseHumansMaleMesenchymal Stem Cell TransplantationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionUmbilical CordCytokinesGlucoseHSP90 Heat-Shock ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCD4+ T cellcytokineglucose metabolismHSP90AA1Lupusmesenchymal stem cellPI3K‐AKT pathway

Identifiers

PMID40801323
PMCPMC12344575

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.