Evidence map›Paper›PMID 40801286›Full record

ArticleSleep2026

Sleep disturbance and cognitive trajectories among older adults with subjective cognitive decline: the roles of age and sleep treatment.

Jing Huang, Nancy A Perrin, Adam P Spira, Sarah L Szanton, George W Rebok, Chakra Budhathoki, Nalaka S Gooneratne, Junxin Li

Abstract read
In one paragraph

Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing HuangSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.ORCID 0000-0001-5512-9758
Nancy A PerrinSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.
Adam P SpiraDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.ORCID 0000-0003-1507-0995
Sarah L SzantonSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.
George W RebokDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Chakra BudhathokiSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.
Nalaka S GooneratnePerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Junxin LiSchool of Nursing, Johns Hopkins University, Baltimore, MD, United States.ORCID 0000-0001-9798-5456

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Cognitive progression among older adults with subjective cognitive decline and mild cognitive impairment: the roles of sleep and physical frailtyK00AG088437 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI Jing Huang · 2025 to 2026
$207k
Cognitive progression among older adults with subjective cognitive decline and mild cognitive impairment: the roles of sleep and physical frailtyF99AG088437 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUANG, JING · 2024 to 2024
$50k
NIA NIH HHS F99 AG088437NIA NIH HHS F99AG088437NIA NIH HHS K00 AG088437NIA NIH HHS NIA U01AG009740NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

STUDY

objectivesGrowing evidence indicates that subjective cognitive decline, characterized by self-reported cognitive deterioration without measurable cognitive impairment, may be an early indicator of Alzheimer's Disease. This study investigated the association between baseline sleep disturbance and a 10-year trajectory of global cognitive performance in adults with subjective cognitive decline and examined if this association was moderated by age (50-64 years and ≥65 years) and sleep treatment.

methodsUsing six waves (2010-2020) of the Health and Retirement Study, we included individuals aged ≥50 years who reported subjective cognitive decline but had no objective cognitive impairment at baseline (2010) and had the final wave of cognitive data (N = 1372). Latent growth curve modeling was employed to examine the associations between self-reported sleep disturbance and cognitive trajectories from 2010 to 2020, controlling for sociodemographic and health-related factors.

resultsIn the full sample, baseline sleep disturbance was not significantly associated with cognitive change. However, a significant interaction between sleep disturbance and age group was found (β = -0.04, 95% confidence interval [-0.08, -0.003]). Stratified analyses showed that poorer sleep was associated with faster cognitive decline in those aged ≥65 years (β = -0.04, 95% confidence interval [-0.07, -0.005]; n = 558), and using sleep treatment was associated with a reduced impact of sleep disturbance on cognitive decline (β = 0.31, 95% confidence interval [0.02, 0.60]). These associations were not significant in those aged 50-64 years (n = 814).

conclusionsSleep disturbance was an independent risk factor of future cognitive decline in older adults ≥65 years with subjective cognitive decline. Sleep treatment may mitigate this decline, offering a potential intervention strategy.

Indexed as

Cognitive DysfunctionSleep Wake DisordersAgedAge FactorsFemaleHumansLongitudinal StudiesMaleMiddle AgedSelf Reportcognitive trajectoryolder adultssleep disturbancesleep treatmentsubjective cognitive decline

Identifiers

PMID40801286
PMCPMC13335143

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.