Evidence map›Paper›PMID 40801285›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Non-Random Distribution of EMS-Induced Mutations Reveals Preference for Open Chromatin and Expressed Genes in Rice.

Xue-Feng Yao, Yanhong Liu, Zhiyong Li, Guo-Qiang Jiang, Wensheng Wang, Hong Lu, Huihui Li, Zefu Lu, Chun-Ming Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. EMS Mutation and SNP Detection in IntracellularbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xue-Feng YaoKey Laboratory of Plant Molecular Physiology, State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.ORCID https://orcid.org/0000-0001-6496-9783
Yanhong LiuState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zhiyong LiState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Guo-Qiang JiangKey Laboratory of Plant Molecular Physiology, State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.
Wensheng WangState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Hong LuChina Golden Marker Co., LTD, Beijing, 102206, China.
Huihui LiState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zefu LuState Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Chun-Ming LiuKey Laboratory of Plant Molecular Physiology, State Key Laboratory of Forage Breeding-by-Design and Utilization, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China.

Funding

Innovation Program of Chinese Academy of Agricultural Sciences and Young Talent Scientist ProgramNational Natural Science Foundation (NSFC) of China 32230077National Transgenic Research Projects of China 2016ZX08009001006Outstanding Young Scientist FoundationProjects of Key Laboratory of Rice Breeding Innovation in Northern Cold Region of Inner Mongolia in China 2025KYPT0159Strategic Priority Research Program of the Chinese Academy of Sciences XDA24010402
6 · The paper itself

Abstract

Mutagenesis is an effective strategy to generate genetic resources for functional genomics and crop improvement. It is widely accepted that chemical-induced mutations are randomly distributed across the genome. However, the randomness of such mutations remains a matter of scientific debate due to a lack of systematic investigation. Although the basic features of mutations induced by different mutagens are known, it remains unresolved whether these mutations correlate with the chromatin state and gene expression. In this study, genomes of the wild-type and 4,619 mutagenized M3 lines derived from treatment with two concentrations of ethyl methane sulfonate (EMS) are sequenced, identifying over 7 million single-nucleotide mutations (SNP

Indexed as

ChromatinEthyl MethanesulfonateGene Expression Regulation, PlantMutationOryzaGenome, PlantMutagenesisPolymorphism, Single NucleotideChromatinEthyl Methanesulfonatechromatin accessibilityEMS mutagenesisnatural variations

Identifiers

PMID40801285
PMCPMC12533142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.