ArticleImmunity, inflammation and disease2025
Clinical Features of Central Nervous System Complications Caused by the SARS-CoV-2 Omicron Variant.
Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pathogens of the human central nervous system-the major viral pathogens.Journal of neurovirology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundThis study investigated clinical characteristics and cerebrospinal fluid (CSF) features of central nervous system (CNS) complications in adults caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant.
methodsWe retrospectively examined adult patients with coronavirus disease-2019 (COVID-19), with or without CNS complications, hospitalized in China from December 2022 to August 2023.
resultsTwenty-five patients with CNS complications (9 severe, 16 non-severe) and 50 patients without CNS complications were examined. The percentage of patients with severe/critical COVID-19 was relatively higher in the CNS complications group (24% [6/25] vs. 12% [6/50]). Procalcitonin and creatine kinase levels, and leukocyte and neutrophil counts were significantly higher in patients with CNS complications. Having severe CNS complications was associated with older age, comorbidities, and elevated creatine kinase and d-dimer levels. Among 22 patients with CNS complications who underwent CSF testing, 10 (45%) had abnormal CSF cytology or biochemistry-including 9 (41%) with elevated protein levels-and 2 (9%) had increased white blood cell counts. Among the CSF samples tested, 2 (12%) and 3 (18%) tested positive for SARS-CoV-2 and autoantibodies respectively.
conclusionsOlder age, comorbidities, and elevated serum creatine kinase and d-dimer levels were risk factors for severe CNS complications in adult patients with COVID-19. SARS-CoV-2 was not detected in the CSF of most patients with CNS complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.