ArticlePediatric pulmonology2025
A New Simple to Use Chest CT Scoring System: Validation Study.
Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundCurrent chest computed tomography (CT) based scoring systems are complex.
objectiveValidity of new simple and easy to use chest CT scoring system was determined in pwCF with varying severity of lung disease. STUDY
designThree pulmonary physicians scored 60 chest CT scans in 30 pwCF, ages 12-60 years, done at initiation and at 1-year on ETI therapy and scores were correlated with ppFEV
resultsInterrater agreement among three raters, determined by intraclass correlation coefficient (ICC) (95% confidence interval [CI]) scores in total cohort, was 0.83 (0.72, 0.91), for bronchiectasis (BEC), 0.83 (0.72, 0.91) for mucus plugging (MP), and for bronchial wall thickness (BWT) and parenchymal lung disease (PLD) was 0.56 (0.35, 0.74) and 0.7 (0.54, 0.83) respectively (all in the moderate to good range). Intrarater reliability (4-6 weeks apart) on 10 pwCF (20 CT scans) in total cohort was excellent, ranging from 0.92 to 0.98. For individual components it was excellent for BEC, good to excellent for PLD and MP, and moderate for BWT. ppFEV
conclusionOur scoring system was validated with acceptable interrater and intrarater agreement and was able to quantify expected changes with therapy.
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