ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Mellitic Acid as a Stable Abiotic Precursor for Liquid-Liquid Phase Separation: An RNA-Independent Pathway for Prebiotic Compartmentalization.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Protein-Independent Liquid-Liquid Phase Separation of Adenosine Triphosphate Under Crowded Conditions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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5 authors.
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Abstract
Apart from playing the well-recognized roles in the self-assembly of intracellular machinery liquid-liquid phase separation (LLPS) constitutes a hypothetical, yet compelling scenario for prebiotic compartmentalization. One challenge facing this idea is the absence (or scarcity) of typical biopolymer precursors of liquid droplets, such as RNA, on early Earth. We demonstrate that mellitic acid (MAc), an abiotic component found in certain minerals and a marker of organic matter in astrobiology, forms liquid droplets with poly-L-lysine (PLL) across a broad pH range and various mixing ratios. The chain-length threshold of PLL capable of forming droplets with MAc ((L-Lys)
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