Evidence map›Paper›PMID 40801026›Full record

ArticleFrontiers in endocrinology2025

Therapeutic effect and mechanism of gigantol on hyperuricemia.

Yuanfan Wu, Xia Sun, Yuhan Jia, Tianshu Gao, Jin Xu, Youqiao Qian, Naiqi Pei, Lilin Wang, Qiaohong Zheng, Honglei Li and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Yuanfan Wu *Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xia Sun *Department of Medicine, Ju Rong Hospital of Traditional Chinese Medicine, Zhenjiang, Jiangsu, China.
Yuhan Jia *School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Tianshu Gao *School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Jin XuDepartment of Nephrology, Jurong Hospital Affiliated to Jiangsu University, Jurong, China.
Youqiao QianCollege of Mudi Meng Honors, China Pharmaceutical University, Nanjing, China.
Naiqi PeiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Lilin WangCollege of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Qiaohong ZhengSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Honglei LiDepartment of Pharmacy, Kangda College of Nanjing Medical University, Lianyungang, China.
Zhen ChenSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Yijiao LiuSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Yang MaSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Hui ChenCollege of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
Yuanyuan YeSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Jiaxin ZhaoSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Yi ZhouSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Xiaoqing ChenSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.
Baosheng HuangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China.
Yefeng LiuDepartment of General Surgery, Jurong Hospital Affiliated to Jiangsu University, Jiangsu, Zhenjiang, China.
Yin ZhuDepartment of General, Jurong Hospital Affiliated to Jiangsu University, Jiangsu, Zhenjiang, China.
Ning XueDepartment of Acupuncture, Jurong Hospital Affiliated to Jiangsu University, Jiangsu, Zhenjiang, China.
Juan ZhangThe Fourth Department of Psychiatry, Shandong Daizhuang Hospital, Shandong, Jining, China.
Guangfeng JiThe Fourth Department of Psychiatry, Shandong Daizhuang Hospital, Shandong, Jining, China.
Xing WangSchool of Pharmacy, China Pharmaceutical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the therapeutic effects of gigantol on hyperuricemia (HUA) and investigate the underlying mechanism of HUA. A mouse model of HUA was made by gavage of potassium oxonate, and HK-2 and AML12 cell models were made by adenosine and xanthine oxidase (XOD) induction. We tested the levels of uric acid (UA), creatinine (CRE), blood urea nitrogen (BUN), cellular UA, and XOD activity. The levels of NOD-like receptor thermal protein domain 3 (NLRP3) and other inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA) kits. XOD is a protein related to the NLRP3 pathway and also serves as an UA transporter. We found that the levels of UA, CRE, and BUN increased in serum but decreased in urine in HUA model mice. After gigantol treatment, UA, CRE, and BUN levels in serum decreased, whereas their levels in urine increased. The levels of NLRP3 and interleukin-1β (IL-1β) were lower and the expression of NLRP3-related protein decreased after gigantol treatment. In conclusion, gigantol exhibits a therapeutic effect on HUA, and the mechanism may be related to inhibiting XOD activity to reduce UA production, regulating the expression of UA transporters to increase UA excretion, and inhibiting the activation of NLRP3 inflammatory signaling.

Indexed as

HyperuricemiaAnimalsDisease Models, AnimalHumansInterleukin-1betaMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinUric AcidXanthine OxidaseInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseUric AcidXanthine OxidasegigantolHUANLRP3UA transportersxanthine oxidase inhibitor

Identifiers

PMID40801026
PMCPMC12339328

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.