Evidence map›Paper›PMID 40801021›Full record

ArticleBioactive materials2025

Biocompatible liquid-infused titanium minimizes oral biofilm adhesion in flow chamber and 3D implant-tissue-biofilm

Katharina Doll-Nikutta, Carina Mikolai, Nils Heine, Kestutis Kurselis, Elena Fadeeva, Nicolas Debener, Beate Legutko, Charlotte Kreuzkamp, Vannila Prasanthan, Janina Bahnemann and 2 more

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katharina Doll-NikuttaDepartment of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Carina MikolaiDepartment of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Nils HeineDepartment of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Kestutis KurselisInstitute of Quantum Optics, Leibniz University Hannover, Hannover, Germany.
Elena FadeevaInstitute of Quantum Optics, Leibniz University Hannover, Hannover, Germany.
Nicolas DebenerInstitute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany.
Beate LegutkoInstitute of Production Engineering and Machine Tools, Leibniz University Hannover, Hannover, Germany.
Charlotte KreuzkampDepartment of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.
Vannila PrasanthanInstitute of Production Engineering and Machine Tools, Leibniz University Hannover, Hannover, Germany.
Janina BahnemannInstitute of Physics, University of Augsburg, Augsburg, Germany.
Boris N ChichkovInstitute of Quantum Optics, Leibniz University Hannover, Hannover, Germany.
Meike StieschDepartment of Prosthetic Dentistry and Biomedical Materials Science, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomedical implants are susceptible to bacterial colonization, which can lead to challenging implant-associated infections. In particular, dental implant abutments - which are continuously exposed to bacteria within the oral cavity - stand to greatly benefit from strategies which inhibit the development of bacterial biofilms. Liquid-infused titanium surfaces have demonstrated excellent biofilm repellency, but to date have not been analyzed with substances suitable for medical device approval in terms of biocompatibility under conditions mimicking the environment of dental implant abutments. In this study, different medical-grade lubricants coated onto laser-structured titanium were screened for stability and water-repellency - with the results suggesting that unmodified structured titanium coated with silicone oil was the most promising combination of materials. When analyzing biofilm formation, the coated surfaces showed a statistically significant reduction in oral commensal

Identifiers

PMID40801021
PMCPMC12341519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.