Evidence map›Paper›PMID 40800945›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Imaging of developing human brains with ex vivo PSOCT and dMRI.

Hui Wang, Nathan Blanke, Dayang Gong, Alpen Ortug, Jose Luis Alatorre Warren, Christopher Clickner, William Ammon, Jackson Nolan, Zoe Cotronis, Andre van der Kouwe and 1 more

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hui WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Nathan BlankeAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Dayang GongAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Alpen OrtugAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Jose Luis Alatorre WarrenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Christopher ClicknerAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
William AmmonAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Jackson NolanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Zoe CotronisAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Andre van der KouweAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.
Emi TakahashiAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States.

Funding

Brainstem Arousal Network in Human Consciousness: Healthy development vs SIDSR01HD102616 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Lilla Zollei · 2021 to 2026
$3.5M
Atypical Formation of Fiber Pathways and Cortical Folding in the BrainR01NS109475 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI (OKI), EMI · 2019 to 2023
$2.3M
Brain Development in Down Syndrome during Fetal and Early Postnatal AgesR01HD111454 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI (OKI), EMI · 2024 to 2024
$1.9M
MRI-based biomarkers for regional brain abnormalities in autism spectrum disorder: From newborns to young adultsR21MH118739 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI TAKAHASHI (OKI), EMI · 2018 to 2019
$487k
Brain Development in Down Syndrome during Fetal, Newborn, and Infant StagesR21HD098606 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI (OKI), EMI · 2019 to 2020
$484k
NICHD NIH HHS R01 HD102616NICHD NIH HHS R01 HD111454NICHD NIH HHS R21 HD098606NIMH NIH HHS R21 MH118739NINDS NIH HHS R01 NS109475
6 · The paper itself

Abstract

The human brain undergoes substantial developmental changes in the first 5 years of life. Particularly in the white matter, myelination of axons occurs near birth and continues at a rapid pace during the first 2 to 3 years. Diffusion MRI (dMRI) has revolutionized our understanding of developmental trajectories in white matter. However, the mm-resolution of

Indexed as

diffusion MRImyelinationneurodevelopmentneuroimagingPolarization-Sensitive Optical Coherence Tomography (PSOCT)white matter anatomy

Identifiers

PMID40800945
PMCPMC12319849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.