Evidence map›Paper›PMID 40800940›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Bundle-specific tractography approach for identifying white matter microstructural changes following traumatic brain injury in rats: An EpiBioS4Rx study.

Akul Sharma, Ryan Cabeen, Neil G Harris, David K Wright, Jussi Tohka, Olli Grohn, Alexis Bennett, Celina Alba, Sweta Bhagavatula, Rachael Garner and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Akul SharmaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Ryan CabeenLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Neil G HarrisUCLA Brain Injury Research Center, Department of Neurosurgery, Geffen Medical School, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
David K WrightThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Jussi TohkaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Olli GrohnA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Alexis BennettLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Celina AlbaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Sweta BhagavatulaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Rachael GarnerLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Tuba AsifriyazLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.
Xavier Ekolle Ndode-EkaneA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Pedro AndradeA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Riikka ImmonenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Eppu ManninenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Noora PuhakkaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Mette HeiskanenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Idrish AliThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Nigel C JonesThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Sandy R ShultzThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Pablo M Casillas-EspinosaThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Matthew R HudsonThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Juliana SilvaThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Glenn YamakawaThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Emma L BraineThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Gregory D SmithUCLA Brain Injury Research Center, Department of Neurosurgery, Geffen Medical School, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Cesar E Santana-GomezDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Richard J StabaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Terence J O'BrienThe Department of Neuroscience, The School of Translational Medicine and Alfred Health, Monash University, Melbourne, Australia.
Asla PitkanenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Dominique DuncanLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) presents a major global health concern, characterized by a variety of negative long-term neurological outcomes. Current diagnostic tools lack the sensitivity to fully capture the complex pathophysiology of TBI and predict long-term consequences, underscoring the need for robust methods for biomarker detection. This study, conducted within the multicenter Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) framework, used a standardized lateral fluid-percussion injury (FPI) model to produce TBI in the left hemisphere of adult male Sprague-Dawley rats across three sites: University of Eastern Finland, Monash University, and the University of California, Los Angeles. This study utilized a novel kernel regression method for improved estimation of fiber orientations and streamline tractography to derive diffusion tensor imaging (DTI) metrics of 36 white matter tracts which were used as features to classify TBI versus sham-operated rodents scanned at 2 days (30 sham, 87 TBI), 9 days (29 sham, 84 TBI), 1 month (28 sham, 81 TBI), and 5 months (25 sham, 65 TBI) post-injury using elastic net regression regularization. A mean area under the curve (AUC) of 0.92 was achieved in correctly classifying the TBI rats in a leave-one-out cross-validation (LOOCV) framework. The results revealed delayed, region-specific effects on the microstructure of the left fimbria and left thalamic subcortical projections at 5 months following TBI. By integrating multi-compartment modeling, tractography, and harmonization, this study advances our understanding of the temporal evolution of TBI pathogenesis, paving the way for development of translational prognostic biomarkers for the risk of post-traumatic epilepsy (PTE).

Indexed as

biomarkersdiffusion tensor imagingfluid-percussion injurymagnetic resonance imagingtractographytraumatic brain injury

Identifiers

PMID40800940
PMCPMC12319758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.