Evidence map›Paper›PMID 40800933›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Toward a standard preoperative MRI protocol for functional neurosurgery.

Christopher Güttler, Johannes Achtzehn, Patric Blomstedt, Stéphan Charbardès, Katharina Faust, Stefan Hetzer, Brian H Kopell, Joachim K Krauss, Andres Lozano, Joseph Neimat and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christopher GüttlerInstitute of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.ORCID https://orcid.org/0000-0003-2448-3986
Johannes AchtzehnMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.ORCID https://orcid.org/0000-0002-0657-6516
Patric BlomstedtDept of Clinical Neuroscience / Unit for Deep Brain Stimulation, University Hospital of Northern Sweden, Umeå, Sweden.
Stéphan CharbardèsDepartment of Neurosurgery, Université Joseph Fourier, Grenoble, France.
Katharina FaustDepartment of Neurosurgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
Stefan HetzerBerlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1773-1518
Brian H KopellNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Joachim K KraussDepartment of Neurosurgery, Hannover Medical School, Hannover, Germany.
Andres LozanoDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-8257-3694
Joseph NeimatDepartment of Neurosurgery, University of Louisville, School of Medicine, Louisville, KY, United States.ORCID https://orcid.org/0000-0002-1114-8938
Francisco A PonceDepartment of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.
Pratik RohatgiDepartment of Neurosurgery, Boston University, Boston, MA, United States.
John RolstonDepartment of Neurosurgery, University of Utah, Salt Lake City, UT, United States.
Mathieu SantinSorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, INSERM, CNRS, Paris, France.
Philip A StarrWeill Institute for Neurosciences, University of California, San Francsico, CA, United States.
Veerle Visser-VandewalleNetwork Stimulation Institute, Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Germany.
Andrea A KühnMovement Disorders and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Andreas HornNetwork Stimulation Institute, Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Germany.
Anna TietzeInstitute of Neuroradiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep Brain Stimulation (DBS) is a well-established approach to treat movement disorders such as Parkinson's Disease, dystonia or essential tremor. For optimal therapy response, accurate electrode placement is critical requiring high signal-to-noise of target areas in preoperative MRI. Currently, imaging protocols vary considerably between DBS centers, making it difficult to compare results or pool data for research purposes. Here, various currently employed MRI sequences from several DBS centers are evaluated regarding their suitability for DBS targeting and a protocol is suggested taking image quality and practical considerations into account. Two healthy subjects (52-year-old female and a 37-year-old male) were each scanned with various sequences (5 T2w, 1 PDw, 4 T2FLAIRw, 2 T2*w, 5 SWI, 2 FGATIR, 1 T1TIR, and 2 QSM techniques) that then were rated by 12 experienced DBS surgeons for their suitability for targeting the subthalamic nucleus (STN), the internal globus pallidus internus (GPi), and the ventrointermediate (VIM) thalamic nucleus. For a subset of sequences, surgeons were asked to identify the optimal DBS target in the STN and GPi. Contrast-to-noise ratios (CNR) were calculated and correlated to intra-rater z-scores and distances of target coordinates. For STN-DBS, surgeons rated T2w, most SWI, QSM, and T2FLAIRw the highest. For GPi-DBS, FGATIR, PDw, and SWI and for VIM-DBS, FGATIR were deemed the most suitable. Higher CNR correlated with higher intra-rater z-scores (R

Indexed as

deep brain stimulationdystoniaessential tremormagnetic resonance imagingParkinson’s diseaseprotocol harmonizationtargeting

Identifiers

PMID40800933
PMCPMC12319828

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.