ArticleImaging neuroscience (Cambridge, Mass.)2025
When age tips the balance: A dual mechanism affecting hemispheric specialization for language.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cerebral Lateralization for Language as a Potential Biomarker for the Broad Autism Phenotype: A Functional Transcranial Doppler Ultrasonography Investigation.Brain and behavior · 2026Article
- Preserved topography, lateralization, selectivity, and functional connectivity of the language network in older brains.Nature communications · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Lifespan oscillatory dynamics in lexical production: A population-based MEG resting-state analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- When age tips the balance: A dual mechanism affecting hemispheric specialization for language.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Atlas for the Lateralized Visuospatial Attention Networks (ALANs): Insights from fMRI and network analyses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- When Age Tips the Balance: a Dual Mechanism Affecting Hemispheric Specialization for Language.bioRxiv : the preprint server for biology · 2023Article
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6 authors.
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Abstract
Aging is accompanied by changes in brain architecture that alter the lateralization of functional networks. In this study, we examined how hemispheric specialization changes across the adult lifespan by analyzing resting-state fMRI and structural MRI data from 728 typical adults aged 18 to 88 years. Using the Language-and-Memory Network atlas, we quantified regional asymmetries in functional connectivity along the cortex's principal gradient, and normalized regional volumes across 37 bilateral regions. We identified two distinct age-related asymmetry trajectories: one pattern revealed a bilateralization of language-dominant regions, while the other showed increasing leftward specialization in multimodal regions associated with memory and language. These opposing patterns emerged around midlife and were linked to performance in language production tasks. By integrating connectivity gradients, structural asymmetries, and behavioral data, our findings provide new evidence for a dual mechanism reshaping functional brain lateralization with age and demonstrate the utility of resting-state metrics in tracking these shifts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.