ArticleImaging neuroscience (Cambridge, Mass.)2025
The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Exploring heart rate variability as a biomarker for frailty: A narrative review.European journal of clinical investigation · 2026Review
- Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distributed fMRI patterns coupled to low-frequency cardiorespiratory dynamics provide markers of aging.bioRxiv : the preprint server for biology · 2025Article
- Functional MRI signatures of autonomic physiology in aging.Communications biology · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
Aging is associated with declines in autonomic nervous system (ANS) function, impaired neurovascular coupling, and diminished cerebrovascular responsiveness-factors that may contribute to cognitive decline and neurodegenerative diseases. Understanding how aging alters the integration of physiological signals in the brain is crucial for identifying potential interventions to promote brain health. This study examines age-related differences in coupling between low-frequency cardiac rate and respiratory volume fluctuations and the blood oxygenation level-dependent (BOLD) signal, using two independent resting-state fMRI datasets with concurrent physiological recordings from younger and older adults. Our findings reveal significant age-related reductions in the percent variance of the BOLD signal explained by heart rate (HR), respiratory variation (RV), and end-tidal CO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.