ArticleImaging neuroscience (Cambridge, Mass.)2025
Dose-response of tDCS effects on motor learning and cortical excitability: A preregistered study.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Transcranial direct current stimulation enhances delayed retention after 5 days of lower-limb motor skill learning.The Journal of physiology · 2026Trial
- Does Anodal Transcranial Direct Current Stimulation Over the Primary Motor Cortex Really Enhance Motor Sequence Learning?Biological psychiatry global open science · 2026Article
- Transcranial Direct Current Stimulation for Stroke Motor Recovery: What the TRANSPORT2 Trial Taught Us.Stroke · 2026Review
- Absence of evidence for post-training tDCS effects on motor memory consolidation and premotor-primary motor cortex interaction: a resting-state EEG study.Frontiers in human neuroscience · 2026Article
- Comparing the effect of transcranial random noise stimulation and transcranial direct current stimulation over the motor cortex on motor performance in men vs. women: a randomized controlled crossover study.Frontiers in human neuroscience · 2025Article
- Dose-response relationships in transcranial brain stimulation: Physics, physiology and mechanism.Brain stimulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Multiple studies have demonstrated that transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) can influence corticospinal excitability and motor skill acquisition. However, the evidence for these effects is inconsistent, and a common neural substrate for these effects has not been directly demonstrated. To address this, we hypothesized that higher tDCS intensities would produce more robust effects, and uncover their relationship. In this preregistered study, 120 participants engaged in a motor skill learning task while receiving tDCS with posterior-to-anterior currents through M1. We employed a double-blind, between-subjects design, with groups of 4 mA, 6 mA, or sham stimulation, while ensuring balanced groups in terms of typing speed. Cortical excitability was assessed via motor-evoked potentials (MEPs) and TMS-evoked potentials (TEPs) before and after motor skill learning with concurrent tDCS. tDCS at these higher intensities was well tolerated, and motor learning correlated with pretraining typing speed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.