ArticleImaging neuroscience (Cambridge, Mass.)2025
Revealing layer-specific cortical activity in human M1 using high-resolution line-scanning fMRI.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A synthetic 3D human cerebrovascular model informed by histology for simulating the cortical depth-dependent BOLD fMRI signal.PLoS computational biology · 2026Article
- Large gains in SNR through the application of Shinnar-Le Roux RF pulse design to short-TR spin-echo fMRI acquisitions at 7 T.Magnetic resonance imaging · 2026Article
- Therapeutic effect of mirror visual feedback therapy on neuropathic pain in patients with total brachial plexus injuries.Frontiers in neurology · 2026Article
- Laminar CBV and BOLD response characteristics over time and space in the human primary somatosensory cortex at 7T.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
4 authors.
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Abstract
In recent years, ultra-high field functional MRI has allowed researchers to study cortical activity at high spatiotemporal resolution. Advancements in technology have made it possible to perform fMRI of cortical laminae, which is crucial for understanding and mapping of local circuits and overall brain function. Unlike invasive electrophysiology, fMRI provides a non-invasive approach to studying human and animal brain function. However, achieving high spatial resolution has often meant sacrificing temporal resolution. In contrast, line-scanning fMRI maintains both high spatial and temporal resolution, and has been successfully applied to animals to detect laminar differences of the hemodynamic response. Although this method has been extended to human brain imaging in initial studies, staying within SAR safety limits while maintaining a well-defined saturation profile at a short TR is a major challenge. We present a method for gradient-echo-based human line-scanning that uses four saturation regions to achieve a line with narrow FWHM (3.9 mm) at high spatiotemporal resolution (voxel size 0.39 x 3.0 x 3.0 mm
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