ArticleImaging neuroscience (Cambridge, Mass.)2025
Measuring the neurodevelopmental trajectory of excitatory-inhibitory balance via visual gamma oscillations.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Developmental and aging trajectories of 40-Hz auditory steady-state responses: A systematic review across the human lifespan.Developmental cognitive neuroscience · 2026Pooled it
- Role of neural oscillations in depression: highlights on gamma oscillations.Translational psychiatry · 2026Review
- Revolutionizing Pediatric Neurophysiology With Magnetoencephalography.Psychophysiology · 2026Review
- Optimizing OPM-MEG Sensor Layouts Using the Sequential Selection Algorithm with Simulated Sources and Individual Anatomy.Sensors (Basel, Switzerland) · 2026Article
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
- Expanding the toolkit: OPMs for studying the developing brain.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Potential ofEpilepsia open · 2025Article
- Superconducting Quantum Magnetometers for Brain Investigations.Sensors (Basel, Switzerland) · 2025Review
- Assessing the stability of evoked, induced, and passive MEG responses for repeat testing with optically pumped magnetometers.Scientific reports · 2025Article
- Towards a 384-channel magnetoencephalography system based on optically pumped magnetometers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Disruption of the balance between excitatory and inhibitory neurotransmission (E-I balance) is thought to underlie many neurodevelopmental disorders; however, its study is typically restricted to adults, animal models, and the lab-bench. Neurophysiological oscillations in the gamma frequency band relate closely to E-I balance, and a new technology-OPM-MEG-offers the possibility to measure such signals across the lifespan. We used OPM-MEG to measure gamma oscillations induced by visual stimulation in 101 participants, aged 2-34 years. We demonstrate a significantly changing spectrum with age, with low-amplitude broadband gamma oscillations in children and high-amplitude band limited oscillations in adults. We used a canonical cortical microcircuit to model these signals, revealing a significant decrease in the ratio of excitatory to inhibitory signalling with age in the superficial pyramidal neurons of the visual cortex. Our findings detail the first MEG metrics of gamma oscillations and their underlying generators from toddlerhood, providing a benchmark against which future studies can contextualise.
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