ArticleImaging neuroscience (Cambridge, Mass.)2025
Attenuated and delayed neural activity in cortical microcircuitry of monocular processing and binocular interactions in human amblyopia.
Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Neurovascular Coupling Disruption and Glymphatic Dysfunction Are Associated With Visual Impairment in Pediatric Monocular Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2026Article
- Spatiotemporal Dynamics of Binocular Interaction in Anisometropic Amblyopia Revealed by Classification Image.Investigative ophthalmology & visual science · 2026Article
- Neurophysiological basis for visual distortions in amblyopia.Frontiers in neuroscience · 2026Review
- Loss and recovery of neurofilament in the cat lateral geniculate nucleus following monocular retinal inactivation.Frontiers in neuroscience · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Disruption of retinal input early in life can lead to amblyopia, a condition characterized by reduced visual acuity after optical correction. While functional abnormalities in the early visual areas have been observed in amblyopia, mesoscale deficits in cortical microcircuitry across cortical depth remain unexplored in humans. Using a combination of submillimeter 7T fMRI and EEG frequency-tagging methods, we investigated neural deficits in monocular processing and binocular interactions in human adults with unilateral amblyopia. The results revealed attenuated and delayed monocular activity in the thalamic input layers of V1, followed by imbalanced binocular suppression and weakened binocular integration in the superficial layers. These disruptions further reduced visual signal strength and processing speed. Our findings pinpoint specific neural deficits in the cortical microcircuitry associated with human amblyopia, offering valuable insights into the mesoscale mechanisms of developmental plasticity and paving the way for more effective treatments for this visual disorder.
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