Evidence map›Paper›PMID 40800832›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Estimation of oxygen extraction fraction based on hemodynamic measurements using DSC-MRI.

Lasse Stensvig Madsen, Malene Kaasing Thomsen, Hugo Angleys, Irene Klærke Mikkelsen, David James Brooks, Simon Fristed Eskildsen, Leif Østergaard

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lasse Stensvig MadsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-5721-9885
Malene Kaasing ThomsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Hugo AngleysCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-7361-7798
Irene Klærke MikkelsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-1738-9038
David James BrooksDepartment of Nuclear Medicine and PET-Centre, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-2602-2518
Simon Fristed EskildsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-4242-9158
Leif ØstergaardCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-2930-6997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxygen availability in brain tissue is closely linked to local hemodynamics and even slight disturbances in the cerebral microcirculation may damage cells due to the brain's high energy demands. In addition to local cerebral blood flow, knowledge of the oxygen extraction fraction (OEF) is critical when assessing brain tissue oxygenation. A biophysical model that relates the brain's microvascular hemodynamics to OEF has previously been proposed. Here, we aimed to calibrate and compare this model with OEF measurements determined by [

Indexed as

capillary transit time heterogeneitydynamic susceptibility contrastmagnetic resonance imagingoxygen extraction fractionpositron emission tomography

Identifiers

PMID40800832
PMCPMC12319796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.