Evidence map›Paper›PMID 40800788›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Molecular connectivity studies in neurotransmission: a scoping review.

Mario Severino, Débora Elisa Peretti, Marjorie Bardiau, Carlo Cavaliere, Matthieu Doyen, Gabriel Gonzalez-Escamilla, Tatiana Horowitz, Martin Nørgaard, Jhony Alejandro Mejia Perez, Matej Perovnik and 18 more

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Mario SeverinoDepartment of Information Engineering, University of Padua, Padua, Italy.ORCID https://orcid.org/0009-0008-8361-6228
Débora Elisa PerettiLaboratory of Neuroimaging and Innovative Molecular Tracers, University of Geneva, Geneva, Switzerland.
Marjorie BardiauULiège Library, University of Liège, Liège, Belgium.
Carlo CavaliereIRCCS SYNLAB SDN, Naples, Italy.
Matthieu DoyenUniversité de Lorraine, IADI, INSERM U1254, Nancy, France.
Gabriel Gonzalez-EscamillaDepartment of Neurology, Focus Program Translational Neuroscience, Rhine-Main, Neuroscience Network, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
Tatiana HorowitzDepartment of Nuclear Medicine, Timone Hospital, AP-HM, Aix Marseille Univ, CERIMED, CNRS, Centrale Marseille, Institut Fresnel, Marseille, France.
Martin NørgaardDepartment of Computer Science, University of Copenhagen, Copenhagen, Denmark.
Jhony Alejandro Mejia PerezMemory and Aging Centre, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.
Matej PerovnikDepartment of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Michael RullmannDepartment of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
Dilara SteenkenDepartment of Nuclear Medicine, TUM School of Medicine and Health, Munich, Germany.
Daniel TalmasovDepartments of Neurology and Psychiatry, Columbia University Irving Medical Centre, New York, NY, United states.
Chunmeng TangNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Tommaso VolpiDepartment of Radiology and Biomedical Imaging, PET Centre, Yale University, New Haven, CT, United States.
Zhilei XuDivision of Neuro, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Alessandra BertoldoDepartment of Information Engineering, University of Padua, Padua, Italy.
Vince D CalhounTri-Institutional Centre for Translational Research in Neuroimaging and Data Science (TRenDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, United States.
Silvia Paola CaminitiDepartment of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.
Xin DiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United states.
Christian HabeckCognitive Neuroscience Division, Department of Neurology, Columbia University Irving Medical Centre, New York, NY, United States.
Sharna JamadarSchool of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
Daniela PeraniVita-Salute San Raffaele University, Milan, Italy.
Arianna SalaComa Science Group, GIGAConsciousness, University of Liege, Liege, Belgium.
Vesna SossiDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.
Igor YakushevDepartment of Nuclear Medicine, TUM School of Medicine and Health, Munich, Germany.
Joana B PereiraDivision of Neuro, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Mattia VeroneseDepartment of Information Engineering, University of Padua, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are essential molecular imaging tools for the in vivo investigation of neurotransmission. Traditionally, PET and SPECT images are analysed in a univariate manner, testing for changes in radiotracer binding in regions or voxels of interest independently of each other. Over the past decade, there has been an increasing interest in the so-called

Indexed as

molecular connectivitymolecular imagingneuroimagingneurotransmissionpositron emission tomography

Identifiers

PMID40800788
PMCPMC12319898

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.