Evidence map›Paper›PMID 40800747›Full record

ArticleImaging neuroscience (Cambridge, Mass.)2025

Fiber microstructure quantile (FMQ) regression: A novel statistical approach for analyzing white matter bundles from periphery to core.

Zhou Lan, Yuqian Chen, Jarrett Rushmore, Leo Zekelman, Nikos Makris, Yogesh Rathi, Alexandra J Golby, Fan Zhang, Lauren J O'Donnell

Abstract read
In one paragraph

Article in Imaging neuroscience (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Zhou LanDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Yuqian ChenDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jarrett RushmoreSchool of Medicine, Boston University, Boston, MA, United States.
Leo ZekelmanDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Nikos MakrisCenter for Morphometric Analysis, Department of Psychiatry and Neurology, A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Psychiatric Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Yogesh RathiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Alexandra J GolbyDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Fan ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Lauren J O'DonnellDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

Funding

TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7M
Neural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5M
Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disordersR01MH119222 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN, RATHI, YOGESH · 2019 to 2023
$4.0M
Quantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRIR01NS125781 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEXANDRA J GOLBY, Carl-Fredrik Westin · 2022 to 2026
$3.6M
Unraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography ValidationR01NS125307 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NIKOLAOS MAKRIS, RICHARD Jarrett RUSHMORE · 2022 to 2026
$3.4M
Research Supplement: Naturalistic Neuroimaging for Presurgical Language MappingR01DC020965 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI Einat Liebenthal, Yanmei Tie · 2023 to 2026
$2.7M
Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6M
Elucidating the Three-Dimensional Organization of the Human Cerebellar Cortex Using Histological and Ultra-High Resolution Structural MRI ApproachesR21NS136960 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MAKRIS, NIKOLAOS, RUSHMORE, RICHARD JARRETT · 2024 to 2025
$472k
NIA NIH HHS R01 AG042512NIBIB NIH HHS P41 EB028741NIDCD NIH HHS R01 DC020965NIMH NIH HHS R01 MH119222NIMH NIH HHS R01 MH125860NIMH NIH HHS R01 MH132610NINDS NIH HHS R01 NS125307NINDS NIH HHS R01 NS125781NINDS NIH HHS R21 NS136960
6 · The paper itself

Abstract

The structural connections of the brain's white matter are critical for brain function. Diffusion MRI tractography enables the in-vivo reconstruction of white matter fiber bundles and the study of their relationship to covariates of interest, such as neurobehavioral or clinical factors. In this work, we introduce Fiber Microstructure Quantile (FMQ) Regression, a new statistical approach for studying the association between white matter fiber bundles and scalar factors (e.g., cognitive scores). Our approach analyzes tissue microstructure measures based on

Indexed as

brain-behavior associationdiffusion MRIhuman connectome project young adultquantile regressionscalar factortractographywhite matter

Identifiers

PMID40800747
PMCPMC12319761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.