Mechanical circulatory support for infarct-related cardiogenic shock: a systematic review, pairwise and network meta-analysis.

Zaran Butt, Saad Sharif, Mohammed Ahmad, Michael J Daly, James O'Neill, Aleksandra Gentry-Maharaj, Peter J Godolphin

Abstract read

In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

CytoSorbBiomedicines · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zaran ButtMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, WC1V 6LJ London, UK.ORCID https://orcid.org/0000-0001-7744-6121

Saad SharifDepartment of Cardiology, Connolly Hospital, Blanchardstown, D15 X40D Dublin, Ireland.

Mohammed AhmadDepartment of Cardiology, Connolly Hospital, Blanchardstown, D15 X40D Dublin, Ireland.

Michael J DalyDepartment of Cardiology, Connolly Hospital, Blanchardstown, D15 X40D Dublin, Ireland.

James O'NeillDepartment of Cardiology, Connolly Hospital, Blanchardstown, D15 X40D Dublin, Ireland.

Aleksandra Gentry-MaharajMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, WC1V 6LJ London, UK.

Peter J GodolphinMRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, WC1V 6LJ London, UK.ORCID https://orcid.org/0000-0003-0648-0992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Mortality from cardiogenic shock complicating acute myocardial infarction (AMI-CS) remains high, despite the increasing mechanical circulatory support (MCS) use in clinical practice. Methods and results: We undertook a systematic review and meta-analysis of trials assessing MCS in adults with AMI-CS. We searched Medline, EMBASE, CENTRAL, Web of Science, and Scopus from inception to May 2024. We evaluated the effect of each intervention on early mortality using a random-effects network meta-analysis of odds ratios (ORs). Safety outcomes included stroke, bleeding, and sepsis. Fourteen trials randomizing 1858 patients were included: intra-aortic balloon pump (IABP) vs. medical therapy (four trials, Conclusion: The mortality benefit of MCS devices in AMI-CS remains uncertain. Using such devices may be associated with increased risks, including major bleeding, stroke, and sepsis. Current evidence does not support the routine use of MCS devices in the management of AMI-CS.

Indexed as

Cardiogenic shockIntra-aortic balloon pumpMechanical circulatory supportMyocardial infarctionPercutaneous ventricular assist deviceVeno-arterial extra-corporeal membrane oxygenation

Identifiers

PMID40800680

DOI10.1093/ehjopen/oeaf091

PMCPMC12342370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.