ArticleJBMR plus2025
Prevalence of enthesopathies in X-linked hypophosphatemia: an explorative ultrasound study.
Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Insight into Natural History and Phenotype in Untreated Adults with X-Linked Hypophosphatemia.Calcified tissue international · 2026Article
- Pain medication use in patients with X-linked hypophosphatemia treated with burosumab: a retrospective real-world study.JBMR plus · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by renal phosphate wasting, leading to rickets in children and osteomalacia in adults. An underrecognized symptom in adults with XLH is enthesopathy, leading to pain and reduced quality of life. Although enthesopathies primarily affect tendon insertions, they are closely linked to the underlying bone pathology of XLH, reflecting mineralization defects characteristic of osteomalacia. This study aimed to determine the prevalence of enthesopathies in XLH patients using ultrasound and assess their association with pain and physical function. This cross-sectional study included 26 XLH patients (mean age: 37.9 ± 17.1 yr, 76.9% female). Ultrasound examinations assessed 6 tendons of the upper and 10 tendons of the lower extremity in adolescents and adults with XLH. Laboratory tests included phosphate, alkaline phosphatase, and i-FGF23 levels. Physical performance was evaluated using the 6-min walk test (6MWT) and the chair rising test. Pain was assessed using the brief pain inventory. Enthesopathies were detected by ultrasound in 84.6% of patients, affecting predominantly the lower extremities (80.8%) but also the upper extremities (50%). The quadriceps and achilles tendons were the most frequently affected sites. Enthesopathy prevalence increased with age (
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