Evidence map›Paper›PMID 40800665›Full record

ArticleJBMR plus2025

The skeletal transcriptional response to mechanical load varies with age and tissue compartment in female mice.

Carolyn Chlebek, Maia S Raynor, F Patrick Ross, Marjolein C H van der Meulen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carolyn ChlebekMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853 United States.ORCID https://orcid.org/0000-0003-4782-3912
Maia S RaynorSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, 14853 United States.
F Patrick RossFPR Scientific Consulting, Amherst, MA, 01002 United States.
Marjolein C H van der MeulenMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853 United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Applied in vivo loading, such as tibial compression, leads to robust bone formation in young rodents but diminished anabolic responses in adults. To evaluate age-related differences in biological pathways active with loading, we examined the metaphyseal transcriptomes following in vivo tibial compression in young (10-wk-old) and adult (26-wk-old) female C57Bl/6 mice. Animals underwent 1 bout tibial compression and were euthanized at 1, 3, or 24 h post-loading or loaded for 1 wk (

Indexed as

biomechanics—orthopedicscell/tissue signaling—transcription factorsmolecular pathways—remodelingosteoblastsosteocytes

Identifiers

PMID40800665
PMCPMC12342466

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.