ArticleJournal of surgical case reports2025
Medullary thyroid cancer arising from a thyroid rest: a case report.
Article in Journal of surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Advances in immunotherapy for thyroid malignancies: from molecular targets to clinical outcomes.Frontiers in medicine · 2026Review
- Thyroid Collision Carcinoma: A Case Report.Iranian journal of pathology · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medullary thyroid carcinoma (MTC) is rare and originates from parafollicular C cells and most cases present with a primary thyroid lesion. This report describes a 67-year-old woman with a left-sided neck mass and no evidence of intrathyroidal disease. Positron emission tomography-computed tomography (PET-CT) revealed paratracheal lymphadenopathy; other imaging and TSH were unremarkable. Fine-needle aspiration was inconclusive, and excisional biopsy suggested high-grade metastatic neuroendocrine carcinoma, initially suspected to be pulmonary due to thyroid transcription factor-1 (TTF-1) positivity. Pathology review raised concern for MTC. Endocrine evaluation showed elevated calcitonin (25.4 pg/ml) and carcinoembryonic antigen (CEA) (20.1 ng/ml). She denied personal or family history of thyroid disease or multiple endocrine neoplasia syndromes. Total thyroidectomy with central neck dissection was performed. All thyroid sections stained negative for calcitonin, excluding C cell hyperplasia or intrathyroidal MTC. Lymph node morphology and immunoprofile supported metastatic MTC arising from a thyroid rest. This is a rare entity, with only two other cases documented in the literature.
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