ArticleInternational journal of chronic obstructive pulmonary disease2025
Exploring the Causal Relationship Between Saliva Microbiota Abundance and Chronic Obstructive Pulmonary Disease/Idiopathic Pulmonary Fibrosis: A Two-Sample Mendelian Randomization Study.
Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Differential risk of adverse drug reactions with baricitinib across age groups: integrating real-world pharmacovigilance and genetic causal inference.Therapeutic advances in drug safety · 2025Article
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3 authors.
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Abstract
Background: Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are progressive lung diseases with overlapping risk factors but distinct pathologies. This study employed bidirectional two-sample Mendelian randomization (MR) to explore potential causal relationships between saliva microbiota abundance and the risk of both diseases. Methods: Saliva microbiota abundance datasets were analyzed for forward and reverse causal associations with both diseases. Of 44 datasets, 43 met the inclusion criteria for instrumental variable selection. MR analyses were performed using inverse variance weighted (IVW), MR-Egger, weighted median, and weighted mode methods. Steiger filtering confirmed directionality. Sensitivity analyses included Cochran's Q, MR-Egger intercept, MR-PRESSO, and leave-one-out to assess heterogeneity, pleiotropy, and the influence of individual variants. Results: In forward MR, higher abundance of species Conclusion: This exploratory study suggests potential directional associations between specific salivary microbiota and chronic respiratory diseases.
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