ArticleFrontiers in pediatrics2025
Development and validation of a CD4+/CD8+ ratio-based nomogram to predict plastic bronchitis in pediatric
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of doxycycline treatment with time to first documented MP-RNA negative conversion in pediatric Mycoplasma pneumoniae pneumonia: a retrospective cohort study.Italian journal of pediatrics · 2026Article
- Immune dysregulation inFrontiers in immunology · 2026Review
- Mycoplasma Pneumoniae bronchiolitis and hypoxemia: A retrospective cohort study on risk and prognosis.PloS one · 2025Article
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Authors and funding
7 authors.
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Abstract
Introduction: Plastic bronchitis (PB) is a rare but severe complication of Methods: This single-center, retrospective cohort study was conducted at Fujian Children's Hospital, China, from January 2023 to December 2024. A total of 281 children hospitalized with MPP, including 39 patients who developed PB, were included. Key predictors for nomogram were selected out of 19 variables using least absolute shrinkage and selection operator regression, followed by multivariable logistic regression. Model performance was evaluated through discrimination, calibration, and decision curve analysis (DCA). Internal validation was performed using the Bootstrap method with 1,000 resamples. Results: The nomogram incorporated four independent predictors-fever duration, atelectasis, elevated D-dimer, and reduced CD4+/CD8 + ratio. It demonstrated strong discrimination (AUC = 0.83, 95% CI 0.77-0.90) and calibration (Hosmer-Lemeshow Discussion: CD4+/CD8 + ratio based nomogram provides a practical tool for predicting PB risk in children with MPP, which may facilitate early bronchoscopy leading to improved patient outcomes.
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