ArticleFrontiers in pediatrics2025
Study on the diagnostic and differential value of thalassemia through combined blood routine examination and reticulocyte detection.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to explore the diagnostic and differential values of thalassemia genotypes using combined complete blood count (CBC) and reticulocyte parameter analysis in neonates, considering physiological age-related hematological changes. Methods: A retrospective study was conducted from October 2023 to March 2024 involving 315 neonates in the Huangshi area who underwent thalassemia gene detection, CBC, and reticulocyte analysis. Participants were categorized into a control group ( Results: In both age strata, the α-thalassemia group exhibited significantly higher red blood cell (RBC) counts but lower mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) compared to control and β-thalassemia groups ( Conclusions: Hematological parameters like MCV, MCH, and RDW are effective initial screening indicators for neonatal thalassemia. Integrating reticulocyte analysis with routine CBC enhances screening accuracy and aids in the differential diagnosis of α- and β-thalassemia. This combined, age-stratified approach is valuable for improving early detection and management strategies.
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