A default mode network subsystem supports both item and associative word encoding: Insights from a meta-analysis.

Recent meta-analytic evidence has underscored the significant role of the default mode network (DMN) in facilitating item word encoding. This study builds on this finding through a comprehensive meta-analysis of fMRI-based subsequent memory studies that use words as stimuli. The results highlight several key functions within the DMN. Firstly, the dorsomedial prefrontal cortex (dmPFC) subsystem of the DMN plays a pivotal role in enhancing successful word encoding, suggesting its vital involvement in the semantic processing of incoming verbal information. Secondly, the utility of the dmPFC subsystem extends beyond item word encoding to associative word encoding tasks, demonstrating its broad applicability in verbal information encoding. Thirdly, regions within the left inferior frontal cortex, a core component of the dmPFC subsystem, show increased activity during associative compared to item word encoding, emphasizing their role in integrating verbal information with contextual details. Contrary to previous research that linked the DMN with encoding interference-often attributed to the core subsystem's tendency for mind-wandering-this study highlights the facilitative role of the dmPFC subsystem in memory encoding. The contrasting roles of the DMN subsystems, both interfering and facilitating, challenge traditional views and advocate for a more nuanced understanding of the network's role in memory encoding.