ArticleImaging neuroscience (Cambridge, Mass.)2024
Investigating the effective temporal resolution in a task-based functional MRI experiment at 7 T MRI using a dynamic phantom.
Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Timing Is Everything: How Subtle Timing Changes in MRI Echo Planar Imaging Can Significantly Alter Mechanical Vibrations and Sound Level.Magnetic resonance in medicine · 2026Article
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2 authors.
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Abstract
An increasing number of human fMRI studies aim to discern the time delays between evoked responses under different stimuli conditions in different brain regions. To achieve that, a primary goal is to acquire fMRI data with high sampling rates. This task is now possible with ultra-high field (≥7 T) MRI and the advancement of imaging acceleration methods. Consequently, it becomes imperative to understand what is the actual or effective temporal resolution (ETR) that is realized in given settings of an fMRI experiment. In this study, we utilized a dynamic phantom to reliably repeat a set of scans, generating a "ground truth" signal with controllable onset delays mimicking fMRI responses in a task-based block-designed fMRI. Here, we define the ETR and quantify a scan's ETR using the dynamic phantom. The quantification was performed for various scanning parameters, including echo time (TE), repetition time (TR), voxel size, and contrast-to-noise ratio (CNR). We further show that combining data from multi-echo EPI can improve the ETR (i.e., reduce it). In addition, parameters of the fMRI paradigm were examined, including the blocks' length and density. As tissue properties (e.g., level of iron deposition) affect the CNR and thus change the ETR, we examined the signal rise mimicking not only the cortex, but also the basal ganglia (known for its high iron deposition). Combining multi-echo data, the estimated ETR for the examined scans was 151 ms for a cortex-mimicking setup and 248 ms for a basal ganglia-mimicking setup, when scanning with a sampling time (i.e., TR) of 600 ms. Yet, a substantial penalty was paid when the CNR was low, in which case the ETR was even larger than the TR. A feasibility set of experiments was also designed to evaluate how the ETR is affected by physiological signal fluctuations and the variability of the hemodynamic response. This study shows the viability of studying time responses with fMRI, by demonstrating that a very short ETR can be achieved. However, it also emphasizes the need to examine the attainable ETR for a particular experiment.
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