ArticleImaging neuroscience (Cambridge, Mass.)2024
Sympathetic and parasympathetic central autonomic networks.
Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Functional Connectivity Alterations of the Central Autonomic Network in Multiple Sclerosis: Links to Fatigue and Aerobic Training Effects.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- The brain and heart-axis in neurodegeneration and cardiovascular disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Heart-Brain Temporal Coupling as a Candidate Biomarker of Self-Congruency.Biomedicines · 2026Article
- Cardiovascular Activity Predominantly Modulates Brain Dynamics in Non-REM Sleep Transitions.Annals of the New York Academy of Sciences · 2026Article
- MRI methods for the study of central nervous system involvement in autonomic function.Frontiers in network physiology · 2026Review
- Central autonomic network dysfunction in Stroke-Heart Syndrome: mechanistic roles of the insula and limbic system.Frontiers in neuroscience · 2026Review
- Heart rate variability in epilepsy and its association with disease duration: a retrospective case-control study.Frontiers in neurology · 2026Article
- Case Report: Relief of long-standing severe motion sickness following stellate ganglion block.Frontiers in neuroscience · 2026Article
- Review
- When your heart isn't in it anymore: cardiac correlates of task disengagement.Communications biology · 2025Article
- Cortical and subcortical mapping of the human allostatic-interoceptive system using 7 Tesla fMRI.Nature neuroscience · 2025Article
- Neurophysiological mechanisms underlying cardiovascular adaptations to exercise: A narrative review.Physiological reports · 2025Review
- Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation.Bioelectronic medicine · 2025Review
- Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain using 7 Tesla fMRI.bioRxiv : the preprint server for biology · 2025Article
- Intracortical brain-heart interplay: An EEG model source study of sympathovagal changes.Human brain mapping · 2024Article
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Authors and funding
4 authors.
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Abstract
The central-autonomic network (CAN) comprises brain regions that are functionally linked to the activity of peripheral autonomic nerves. While parasympathetic CAN (i.e., the CAN projecting onto parasympathetic branches) has recently been investigated and is known to be involved in neurological and neuropsychiatric disorders, sympathetic CAN (i.e., the CAN projecting onto sympathetic nerves) has not been fully characterized. Using functional magnetic resonance imaging (fMRI) data from the Human Connectome Project in conjunction with heartbeat dynamics and its orthonormal autoregressive descriptors as a proxy for sympathetic activity estimation, namely, the sympathetic activity index (SAI), we uncover brain regions belonging to the sympathetic CAN at rest. We uncover a widespread CAN comprising both cortical (in all lobes) and subcortical areas, including the cerebellum and brainstem, which is functionally linked to sympathetic activity and overlaps with brain regions driving parasympathetic activity. These findings may constitute fundamental knowledge linking brain and bodily dynamics, including the link between neurological and psychiatric disorders and autonomic dysfunctions.
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