ArticleImaging neuroscience (Cambridge, Mass.)2024
Approximation of bone mineral density and subcutaneous adiposity using T1-weighted images of the human head.
Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Changes in human skull bone marrow during pregnancy and postpartum: an exploratory case report.BMC pregnancy and childbirth · 2026Article
- Longitudinal MRI-based changes in intracranial volume and skull thickness observed in both metachromatic leukodystrophy and multiple sclerosis.NeuroImage. Clinical · 2026Article
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Abstract
Bones and brain are intricately connected and scientific interest in their interaction is growing. This has become particularly evident in the framework of clinical applications for various medical conditions, such as obesity and osteoporosis. The adverse effects of obesity on brain health have long been recognised, but few brain imaging studies provide sophisticated body composition measures. Here, we propose to extract the following bone- and adiposity-related measures from T1-weighted MR images of the head: an approximation of skull bone mineral density (BMD), skull bone thickness, and two approximations of subcutaneous fat (i.e., the intensity and thickness of soft non-brain head tissue). The reliability and validity of these four distinct measures were tested in two large-scale databases, the UK Biobank and OASIS-3. The measures pertaining to skull BMD, skull bone thickness, and intensity-based adiposity proxy proved to be reliable (ICC = .95/.83/.66,
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