ArticleImaging neuroscience (Cambridge, Mass.)2024
Challenges in the measurement and interpretation of dynamic functional connectivity.
Article in Imaging neuroscience (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Static and Dynamic Resting-State fMRI Connectivity Show Frequency-Resolved Associations With Intracranial EEG Connectivity.Human brain mapping · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial.Biological psychiatry global open science · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Changes in resting-state functional connectivity linked to affective symptoms: insights from a population-based study of adolescents and young adults.Translational psychiatry · 2026Article
- An Orthogonal Semi-Nonnegative Matrix Factorization Method for Dynamic Functional Connectivity Analysis and Its Application to Schizophrenia.IEEE journal of biomedical and health informatics · 2026Article
- System identification and surrogate data analyses imply approximate Gaussianity and non-stationarity of resting-brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Dynamic, state-dependent characteristics of cognitive fluctuations in Lewy body dementia: a magnetoencephalography study.Brain communications · 2026Article
- Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention.Communications biology · 2025Observational
- A dynamic framework of brain functional patterns shaped by spontaneous thoughts beyond the default mode network.Scientific reports · 2025Article
- Time Persistence of the FMRI Resting-State Functional Brain Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Group-to-individual generalizability and individual-level inferences in cognitive neuroscience.Neuroscience and biobehavioral reviews · 2025Review
- Artificial Intelligence and Neuroscience: Transformative Synergies in Brain Research and Clinical Applications.Journal of clinical medicine · 2025Review
- Aberrant static and dynamic brain functional topological organization in the differentiation of myelin oligodendrocyte glycoprotein antibody-seropositive optic neuritis from seronegative optic neuritis.Frontiers in neuroscience · 2025Article
- Spatiotemporal dynamics of EEG microstate networks over the first two years of life: A multi-cohort longitudinal study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Thought contents during rest account for functional connectivity-behavior associations.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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Abstract
In functional MRI (fMRI), dynamic functional connectivity (dFC) typically refers to fluctuations in measured functional connectivity on a time scale of seconds. This perspective piece focuses on challenges in the measurement and interpretation of functional connectivity dynamics. Sampling error, physiological artifacts, arousal level, and task state all contribute to variability in observed functional connectivity. In our view, the central challenge in the interpretation of functional connectivity dynamics is distinguishing between these sources of variability. We believe that applications of functional connectivity dynamics to track spontaneous cognition or as a biomarker of neuropsychiatric conditions must contend with these statistical issues as well as interpretative complications. In this perspective, we include a systematic survey of the recent literature, in which sliding window analysis remains the dominant methodology (79%). We identify limitations with this approach and discuss strategies for improving the analysis and interpretation of sliding window dFC by considering the time scale of measurement and appropriate experimental controls. We also highlight avenues of investigation that could help the field to move forward.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.